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作者：路透社 来自：路透社 发布时间：2004-3-17 |
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 据一项小型初步研究的结果显示，对于因爱滋病毒（HIV）感染导致神经损伤的人而言，抽大麻似乎可以缓解其所承受的痛苦。多发性神经病变（polyneuropathy）对于很多受HIV感染的患者而言是个相当重大的问题。加州大学旧金山分校的杰伊博士（Dr. Cheryl Jay）及同事在本周举行的第11届逆转滤过性病毒年会（Annual Retrovirus Conference）中表示，临床前研究结果显示，大麻类混合物可能有效地治疗神经性疼痛。在一项持续七天的试验中，16名罹患神经性疼痛的HIV感染患者每天抽三支大麻烟。大麻烟是由旧金山综合医院（San Francisco General Hospital）药房发放，而所有患者都曾经抽过大麻，但在试验前30天内均未使用。试验对象中有14人是男性，他们的平均年龄为43岁。他们受神经性疼痛困扰时间平均为6年。患者的疼痛减轻程度按照0至100的虚拟指数进行评估。试验目标是使每日的疼痛平均减轻程度达到30%。杰伊博士向路透表示：“这在疼痛研究中是一个非常典型的标准，而这项病痛减轻程度也是被视为在临床上具有意义的。”患者的平均疼痛指数从研究开始时的47降低至七天研究结束时的20。杰伊博士称，16名患者中有12人达到疼痛减轻30%的目标。她补充说，目前展开新的研究，将随机指定研究对象使用大麻或安慰剂；所需的50名研究对象，目前已招募到20人。 Marijuana Eases HIV-Related Nerve PainThu February 12, 2004 05:29 PM ETSAN FRANCISCO (Reuters Health) - For people with nerve damage that can result from HIV infection, smoking marijuana seems to relieve the pain they experience, according to the results of a small pilot study.Diffuse nerve pain, or polyneuropathy, is a significant problem for many people with HIV infection. Pre-clinical research findings suggest that cannabis-like compounds may be effective for treating neuropathic pain, Dr. Cheryl Jay of the University of California, San Francisco and colleagues noted this week at the 11th Annual Retrovirus Conference.In a trial, 16 HIV-infected subjects with neuropathy were given three marijuana cigarettes each day for seven days. The cigarettes were dispensed by the pharmacy at San Francisco General Hospital. All of the patients reported previous experience smoking marijuana but had not done so for 30 days prior to the trial.Fourteen of the participants were men, and their average age was 43 years. They had had neuropathy for an average of 6 years.Reductions in pain were assessed using a 0-to-100 visual scale. The aim was to achieve a 30 percent reduction in average daily pain, "which is a pretty typical standard used in pain studies, and is considered a clinically meaningful amount of pain relief," Jay told Reuters Health.Average pain scores dropped from 47 at the start of the study to 20 at the end of the seven-day period. Twelve of the 16 participants reached the 30-percent goal in reduction of pain, Jay said.A trial with participants randomized to receive marijuana or an inactive placebo has now been started, she added, and 20 out of 50 participants have been enrolled so far. |
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